This is a meme that has been around for a while - generally all that the memester does is puts an explanation of a situation above this image, and then posts it. The situation is usually a situation where someone is made aware of something suddenly, but it might also be a situation where something suddenly becomes more urgent suddenly, or arrives suddenly.
In this particular instance, the thing that is being pointed out is that hand sanitizer makes one aware of the cuts that are on their hands that they didn't remember about when they started to apply it (due to the stinging sensation of the cuts as they enter the open wound.)
This is a unfortunate occurrence, so this probably qualifies as a joke about misfortune.
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